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The effect the intercurrent use strychnia and chloral rather peculiar, in that after the administration an animal a large and even dangerous dose chloral, a dose strychnia five or six times the ordinary medicinal close may safely administered and even a dose either drug which fatal the same species and size animal not usually followed death yet the chloral must the first drug administered, or a fatal effect will follow. Clinical experience, as well as experiments the lower animals, shows also that chloral has a somewhat feeble property controlling the tetanic spasms induced an overdose strychnia. It has not, however, best writing paper dissertation online dissertation writers in london such efficient action in this respect as the inhalation chloroform. Chloral has a beneficial effect in benumbing sensibility in certain forms pain, as in nienorrhagia, parturition, and the muscular pains occurring after an alcoholic debauch. This effect may theoretically explained the basis arresting the muscular irritability and the interstitial nutrition muscular tissue.

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Its toxic effect upon the muscular contractility tha heart now well The medicinal action chloral, in addition its hypnotic effects, has been proved in certain forms convulsions and spasms a reflex character, and may thus prescribed in infantile convulsions, tetanus, hydrophobia, laryngismus stridulus, in whooping-cough, etc. Its action upon decayed tissue and in offensive discharges aseptic, and may used for this purpose in five ten per cent, watery solutions. In uterine cancer, injections such a solution diminish the fetor and some extent relieve pain. Chloral narcosis should treated, as in other forms narcosis, external and internal stimulation.

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An obstinate and disagreeable itching rash sometimes follows the continued use chloral and may even interfere with its use. Conjunctivitis, paronychia and purpura have also been noticed under the same circumstances.

Chloral usually administered in solution the mouth.

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It should well diluted and the somewhat acrid taste covered a syrup or simple elixir.

It well absorbed from the rectum, and may.

very conveniently administered enema, thus avoiding the disagreeable taste.

In this case, also, should given in dilute solution. It has been proposed administer intravenous injection as a surgical anaesthetic, and in the treatment tetanus, but the troubles and dangers the method seem more than counterbalance its advantages, although there can no doubt that complete anaesthesia may thus produced.

Experience has shown that the doses chloral proposed when was first introduced into practice were much too large, and the tendency has been decidedly reduce them. Hence may say that when administered an adult for the first Dose from eight fifteen grains, half a gramme a gramme. which may once or twice repeated. Under special circumstances, like alcoholism or convulsions, the commencing dose may larger twenty thirty grains, a gramme and a half two grammes. Chloroform specially, like ether, an anaesthetic, and its action most rapid inhalation. As the progress anesthesia described in de tail under the head Ether, unnecessary describe here. 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